Propofol induces metabolic reprogramming and cell death in a mitochondrial electron transport chain-dependent manner
نویسندگان
چکیده
Chisato Sumi, Akihisa Okamoto, Hiromasa Tanaka, Kenichiro Nishi, Munenori Kusunoki, Tomohiro Shoji, Takeo Uba, Yoshiyuki Matsuo, Takehiko Adachi, Jun-Ichi Hayashi, Keizo Takenaga and Kiichi Hirota 1 Department of Anesthesiology, Kansai Medical University, Hirakata, Japan, 2 Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, Hirakata, Japan, 3 Department of Anesthesiology, Tazuke Kofukai Medical Institute Kitano Hospital, Osaka, Japan, 4 University of Tsukuba, Tsukuba, Japan, 5 Department of Life Science, Shimane University Faculty of Medicine, Izumo, Japan
منابع مشابه
Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner
The intravenous anesthetic propofol (2,6-diisopropylphenol) has been used for the induction and maintenance of anesthesia and sedation in critical patient care. However, the rare but severe complication propofol infusion syndrome (PRIS) can occur, especially in patients receiving high doses of propofol for prolonged periods. In vivo and in vitro evidence suggests that the propofol toxicity is r...
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